Collaborative multidisciplinary workshop report: what questions regarding the role of Chlamydia pneumoniae in atherosclerosis and cardiovascular disease need to be addressed utilizing animal models?
نویسندگان
چکیده
Ignatius W. Fong, Thomas Quinn, Erwin Blessing, Cho-chou Kuo, Raffaele Malinverni, Michael Lauer, Steven Mawhorter, Kurt Bachmaier, Michael Rosenfeld, Christopher Taylor, and Guangming Zhong Department of Medicine, University of Toronto, St. Michael’s Hospital, and Amgen Institute, Toronto, and Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada; Division of Infectious Diseases, Johns Hopkins Hospital, Baltimore, and National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Department of Pathobiology and Department of Pathobiology and Pathology, University of Washington, Seattle, Washington; Department of Medicine, Hôpital des Cadolles, Neuchâtel, Switzerland; Department of Cardiology and Department of Infectious Disease, Cleveland Clinic Foundation, Cleveland, Ohio
منابع مشابه
Chlamydia pneumoniae-induced atherosclerosis in a rabbit model.
In order to establish a causative relationship between Chlamydia pneumoniae and atherosclerosis, animal models have been proposed. In a rabbit model, arterial intimal thickening has been induced by direct intravascular and intranasal inoculation with C. pneumoniae. C. pneumoniae infection can induce significant acceleration of atherosclerosis in a mildly hyperlipidemic rabbit model but is preve...
متن کاملChlamydia pneumoniae and cardiovascular disease.
Chlamydia pneumoniae is a ubiquitous pathogen that causes acute respiratory disease. The spectrum of C. pneumoniae infection has been extended to atherosclerosis and its clinical manifestations. Seroepidemiologic studies have associated C. pneumoniae antibody with coronary artery disease, myocardial infarction, carotid artery disease, and cerebrovascular disease. The association of C. pneumonia...
متن کاملCollaborative multidisciplinary workshop report: the role of epidemiology studies in determining a possible relationship between Chlamydia pneumoniae infection and atherothrombotic diseases.
David Siscovick, Russell Alexander, Michael Davidson, Maija Leinonen, Siobhan O’Connor, Paul Ewald, Cristopher Meier, Mirja Puolakkainen, James Hughes, and Javier Nieto Cardiovascular Health Research Unit, and Department of Epidemiology, University of Washington; MedStar Research Institute, Washington, DC; National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atla...
متن کاملChlamydia pneumoniae as an emerging risk factor in cardiovascular disease.
Recent appreciation of atherosclerosis as a chronic, inflammatory disease has rekindled efforts to examine the role that infectious agents may play in atherogenesis. In particular, much interest has focused on infection with Chlamydia pneumoniae. The possibility that a prokaryote contributes to atherogenesis has high clinical interest, as C pneumoniae infection may be a treatable risk factor. T...
متن کاملHigh Sensitivity C–Reactive Protein and Im-munoglobulin G against Chlamydia Pneumo-niae and Chlamydial Heat Shock Protein-60 in Ischemic Heart Disease
Background: Inflammation and infectious agents such as Chlamydia pneumoniae have been associated with cardiovascular disease. Objective: To evaluate the serum high sensitivity C - reactive protein (hs-CRP) and antibodies against Chlamydia pneumoniae and Chlamydial heat shock protein-60 (Cp-HSP60) in patients with ischemic heart disease (IHD). Methods: 62 patients with IHD having either acute my...
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ورودعنوان ژورنال:
- The Journal of infectious diseases
دوره 181 Suppl 3 شماره
صفحات -
تاریخ انتشار 2000